The 17-month-old boy was killed after being struck by a Toyota Rav-4 at the Ibis Hotel in Salford shortly after 9pm on Thursday.
Greater Manchester Police said the boy died at the scene.
Officers from the GMP Serious Collision Investigation Unit (SCIU) are investigating the incident but said, at this time, there are no suspicious circumstances.
Police Sergeant Brian Orr said: "This was a heart-breaking incident involving a young boy which has understandably left his family distraught and the thoughts of everyone in the SCIU are with them at this terrible time.
"At the moment this appears to have been a truly tragic accident and not a suspicious incident; however we have launched an investigation to establish a full understanding of exactly what happened.
"I would ask that anybody who witnessed the collision to please contact police."